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September 11 attacks
The September 11 attacks (also referred to as 9/11) were a series of four coordinated terrorist attacks by the Islamic terrorist group al-Qaeda against
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[Insights Secure – 2018] Daily UPSC Mains Answer Writing Practice: 11 SEPTEMBER 2018
[Insights Secure – 2018] Daily UPSC Mains Answer Writing Practice: 11 SEPTEMBER 2018 Click on EACH question to post/upload you answers. How to Follow Secure Initiative? How to Self-evaluate your answer? LIST of TOPICS (Static) General Studies – 1 Topic– Salie…
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Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
Tatu Pantsar, Sami Rissanen, Daniel Dauch, Tuomo Laitinen, Ilpo Vattulainen, Antti Poso
Author summary The oncogene KRAS is frequently mutated in various cancers. When the amino acid glycine 12 is mutated, KRAS protein acquires oncogenic properties that result in tumor cell-growth and cancer progression. These mutations prevail especially in the…
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Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?
Nicole Marquardt, Malte Feja, Hana Hünigen, Johanna Plendl, Lena Menken, Heidrun Fink, Bettina Bert
In the European Union (EU) millions of laboratory mice are used and killed for experimental and other scientific purposes each year. Although controversially discussed, the use of carbon dioxide (CO2) is still permitted for killing rodents according to the Di…
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Providing longer post-fledging periods increases offspring survival at the expense of future fecundity
David López-Idiáquez, Pablo Vergara, Juan Antonio Fargallo, Jesús Martínez-Padilla
The cost of reproduction is a key concept in life-history trade-offs. However, our understanding of the reproductive costs is biased towards measures of reproductive effort obtained before offspring independence. During the post-fledging dependence period (PF…
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Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition
Rosana Gonzalez-Quintial, Anthony Nguyen, Dwight H. Kono, Michael B. A. Oldstone, Argyrios N. Theofilopoulos, Roberto Baccala
Viruses have long been implicated in the pathogenesis of autoimmunity, yet their contribution remains circumstantial partly due to the lack of well-documented information on infections prior to autoimmune disease onset. Here, we used the lymphocytic choriomen…
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